Journal
ACS NANO
Volume 9, Issue 1, Pages 950-960Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn506757x
Keywords
MoS2 nanosheets; iron oxide nanoparticles; chelate-free Cu-64 labeling; multimodal imaging; photothermal therapy
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Funding
- National Basic Research Programs of China (973 Program) [2012CB932600]
- National Natural Science Foundation of China [51222203]
- Jiangsu Natural Science Fund for Distinguished Young Scholars
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
- University of Wisconsin-Madison
- National Institutes of Health [NIBIB/NCI 1R01CA169365, P30CA014520]
- Department of Defense [W81XWH-11-1-0644]
- American Cancer Society [125246-RSG-13-099-01-CCE]
- NATIONAL CANCER INSTITUTE [P30CA014520, R01CA169365] Funding Source: NIH RePORTER
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Theranostics for in vivo cancer diagnosis and treatment generally requires well-designed nanoscale platforms with multiple integrated functionalities. In this study, we uncover that functionalized iron oxide nanoparticles (IONPs) could be self-assembled on the surface of two-dimensional MoS2 nanosheets via sulfur chemistry, forming MoS2-IO nanocomposites, which are then modified with two types of polyethylene glycol (PEG) to acquire enhanced stability in physiological environments. Interestingly, Cu-64, a commonly used positron-emitting radioisotope, could be firmly adsorbed on the surface of MoS2 without the need of chelating molecules, to enable in vivo positron emission tomography (PET) imaging. On the other hand, the strong near-infrared (NIR) and superparamagnetism of MoS2-IO-PEG could also be utilized for photoacoustic tomography (PAT) and magnetic resonance (MR) imaging, respectively. Under the guidance by such triple-modal imaging, which uncovers efficient tumor retention of MoS2-IO-(d)PEG upon intravenous injection, in vivo photothermal therapy is finally conducted, achieving effective tumor ablation in an animal tumor model. Our study highlights the promise of constructing multifunctional theranostic nanocomposites based on 2D transitional metal dichalcogenides for multimodal imaging-guided cancer therapy.
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