Journal
EUROPEAN UROLOGY
Volume 55, Issue 6, Pages 1477-1480Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.eururo.2008.12.036
Keywords
RCC; Renal cancer; Sunitinib; Tyrosine kinase inhibitors; Locally advanced; Thrombus; Neoadjuvant
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The authors present the first case report of complete histologic remission after neoadjuvant sunitinib treatment on primary renal tumour and vena cava thrombus. A 78-yr-old woman with an Eastern Cooperative Oncology Group (ECOG) score of 0 presented with a T3b renal tumour. She refused surgical treatment but agreed to percutaneous biopsy and medical treatment. A Fuhrman III renal cell carcinoma was histologically confirmed on percutaneous biopsy, and sunitinib treatment was administered over 6 mo. A significant objective response was observed for tumour size and thrombus. The patient finally accepted surgical treatment. Pathologic examination concluded with a complete response of primary tumour and thrombus. (C) 2008 European Association of Urology. Published by Elsevier B.V. All rights reserved.
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