Journal
EUROPEAN RESPIRATORY JOURNAL
Volume 37, Issue 5, Pages 1119-1127Publisher
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/09031936.00059810
Keywords
Biomarker; idiopathic pulmonary fibrosis; lung fibrosis; matrix protein; usual interstitial pneumonia
Categories
Funding
- Ministry of Education, Science, Sports and Culture of Japan [21590977, 20591188]
- Ministry of Health, Labor and Welfare in (Japan)
- Okamoto Satoshi Memorial Fund for Pulmonary Fibrosis Research (Tokyo, Japan)
- Japan Science and Technology Agency
- Grants-in-Aid for Scientific Research [20591188, 23591465, 21590977, 22790934, 21591283] Funding Source: KAKEN
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Idiopathic interstitial pneumonias (IIPs) are histopathologically classified into several types, including usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP) and cryptogenic organising pneumonia (COP). We investigated whether periostin, a matrix protein, could be used as a biomarker to assess histopathological types of IIPs. We performed immunohistochemical analyses in each histopathological type of IIP, examined serum levels of periostin in IIP patients and analysed the relationship between serum levels of periostin and the pulmonary functions in patients with idiopathic pulmonary fibrosis (IPF). Periostin was strongly expressed in lungs of UIP and fibrotic NSIP patients, whereas expression of periostin was weak in the lungs of cellular NSIP and COP patients, as well as in normal lungs. Serum levels of periostin in IPF were significantly higher than those of healthy subjects and COP patients. Furthermore, periostin levels in IPF patients were inversely correlated with their pulmonary functions. Thus, we have found that periostin is a novel component of fibrosis in IIP. Periostin may be a potential biomarker to distinguish IIP with fibrosis.
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