Journal
EUROPEAN RESPIRATORY JOURNAL
Volume 37, Issue 3, Pages 523-531Publisher
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/09031936.00021210
Keywords
Airway inflammation; exhaled nitric oxide; incident asthma
Categories
Funding
- National Institute of Environmental Health Sciences [5P30ES007048, 5P01ES011627]
- National Institute of Environmental Health Sciences and the Environmental Protection Agency [5P01ES009581, R826708-01, RD831861-01]
- National Heart, Lung and Blood Institute [5R01HL061768, 5R01HL076647]
- Hastings Foundation
Ask authors/readers for more resources
A substantial body of evidence suggests an aetiological role of inflammation, and oxidative and nitrosative stress in asthma pathogenesis. Exhaled nitric oxide fraction (FeNO) may provide a noninvasive marker of oxidative and nitrosative stress, and aspects of airway inflammation. We examined whether children with elevated FeNO are at increased risk for new-onset asthma. We prospectively followed 2,206 asthma-free children (age 7-10 yrs) who participated in the Children's Health Study. We measured FeNO and followed these children for 3 yrs to ascertain incident asthma cases. Cox proportional hazard models were fitted to examine the association between FeNO and new-onset asthma. We found that FeNO was associated with increased risk of new-onset asthma. Children in the highest FeNO quartile had more than a two-fold increased risk of new-onset asthma compared to those with the lowest quartile (hazard ratio 2.1, 95% CI 1.3-3.5). This effect did not vary with the child's history of respiratory allergic symptoms. However, the effect of elevated FeNO on new-onset asthma was most apparent among those without a parental history of asthma. Our results indicate that children with elevated FeNO are at increased risk for new-onset asthma, especially if they have no parental history of asthma.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available