Journal
ANNALS OF MEDICINE
Volume 47, Issue 1, Pages 74-80Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/07853890.2014.985704
Keywords
Bundle branch block; electrocardiography; prognosis; ventricular conduction disturbance
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Funding
- Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital
- Hospital District of South Ostrobothnia, Seinajoki, Finland
- Signe Niemisto Legacy Fund, Seinajoki, Finland
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Aims. We examined the prognostic impact of eight different intraventricular conduction delays (IVCD) in the standard electrocardiogram (ECG) in a community cohort. Methods and results. Data were collected from 6299 Finnish individuals. During a mean 8.2 years (interquartile range 8.1 to 8.3) of follow-up 640 subjects died (10.2%); 277 (4.4%) were cardiovascular deaths. For both sexes, all-cause and cardiovascular mortality was higher in subjects with IVCD than in those without. In Cox regression analysis after adjustment for age and gender, the hazard ratio for cardiovascular mortality for non-specifi c IVCD was 4.25 (95% confidence interval [CI] 1.95-9.26, P < 0.0001) and for left bundle branch block (LBBB) 2.11 (95% CI 1.31-3.41, P = 0.002). Right bundle branch block (RBBB) was not related to additional mortality, while incomplete RBBB (IRBBB) presented a hazard ratio of 2.24 (95% CI 1.064-4.77, P = 0.036). Conclusions. In the general population, non-specifi c IVCD, LBBB, and IRBBB were associated with increased relative risk for all-cause and cardiovascular mortality. RBBB did not have an impact on cardiovascular mortality either in subjects with or without previous heart disease.
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