Journal
EUROPEAN RESPIRATORY JOURNAL
Volume 33, Issue 2, Pages 398-404Publisher
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/09031936.00142407
Keywords
Curcumin; ischaemia-reperfusion; lung; microvascular permeability; nuclear factor-kappa B; oxidative stress
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Funding
- Shanghai Leading Academic Discipline Project (Shanghai, China). [B115]
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The present study aimed to investigate potential effects of curcumin (CUR) and dexamethasone I on ischaemia-reperfusion (I/R) induced lung injury in rats. Experimental rats were pre-treated with a single i.p. dose of vehicle, CUR (50 mg.kg(-1) or 200 mg.kg(-1)) or DXM (5 mg.kg(-1)), 2 h before anaesthesia and subjected to left lung hilus clamping with 90-min ischaemia followed by 4 h of reperfusion. Pre-treatment with CUR (200 mg.kg(-1) or DXM markedly attenuated I/R-induced barrier disruption, lung oedema, tissue inflammation, hypoxaemia 4 h after reperfusion, and over-activation of nuclear factor-kappa B inflammatory cytokines, myeloperoxidase and malondialdehyde. It appears that curcumin attenuates acute lung injury, probably through improving oxidative stress and inhibiting nuclear factor-kappa B-mediated expression of inflammatory cytokines. Thus, curcumin may be an alternative therapy for improving the outcomes of ischaemia-reperfusion-induced lung injury.
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