Journal
EUROPEAN RESPIRATORY JOURNAL
Volume 32, Issue 6, Pages 1631-1638Publisher
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/09031936.00176807
Keywords
Apoptosis; epithelium; fibroblast; mechanisms; pathogenesis; pulmonary fibrosis
Categories
Ask authors/readers for more resources
Pulmonary fibrosis, is characterised by fibroblast accumulation and alveolar epithelium denudation. Increased apoptosis of alveolar epithelial cells and decreased apoptosis of fibroblasts may play an important role in the pathogenesis of disease. Inflammatory cells can modulate apoptosis of other cell types, both by removal of apoptotic debris and by cytokine production, thus preserving a pro-fibrotic environment. In the present review, some of the mechanisms by which apoptosis may contribute to the pathogenesis of idiopathic pulmonary fibrosis are described.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available