Liver fat volume fraction quantification with fat and water T1 and T2* estimation and accounting for NMR multiple components in patients with chronic liver disease at 1.5 and 3.0 T

To validate a magnitude-based method for fat volume fraction (FVF) quantification in the liver without any dominant component ambiguity problems and with the aim of transferring this method to any imaging system (clinical fields of 1.5 and 3.0 T). MR imaging was performed at 1.5 and 3.0 T using a multiple-angle multiple-gradient echo sequence. A quantification algorithm correcting for relaxation time effects using a disjointed estimation of T-1 and T-2* of fat and water and accounting for the NMR spectrum of fat was developed. Validations were performed on fat-water emulsion at 1.5 and 3.0 T and compared with H-1-MRS. This was followed by a prospective in-vivo comparative study on 28 patients with chronic liver disease and included histology. Phantom study showed good agreement between MRI and MRS. MR-estimated FVF and histological results correlated strongly and FVF allowed the diagnosis of mild (cutoff = 5.5 %) and moderate steatosis (cutoff = 15.2 %) with a sensitivity/specificity of 100 %. FVF calculation worked independently of the field strength. FVF may be a relevant biomarker for the clinical follow-up of patients (1) with or at risk of NAFLD (2) of steatosis in patients with other chronic liver diseases. aEuro cent Non-invasive techniques to diagnose non-alcoholic fatty liver diseases (NAFLD) are important. aEuro cent Liver fat volume fraction quantified using MRI correlates well with histology. aEuro cent Fat volume fraction could be a relevant marker for NAFLD clinical follow-up. aEuro cent Disjointed relaxation time estimation could potentially identify factors contributing to NAFLD.