Journal
EUROPEAN RADIOLOGY
Volume 22, Issue 7, Pages 1430-1441Publisher
SPRINGER
DOI: 10.1007/s00330-012-2379-4
Keywords
Tomography; X-ray computed; Contrast media; Neoplasms; Blood supply; Diagnostic imaging; Methods; Standards; Guideline
Funding
- Cancer Research UK
- National Institute for Health Research in England
- Department of Health for Scotland
- Department of Health for Wales
- Department of Health for Northern Ireland
- MRC [G0701945] Funding Source: UKRI
- Medical Research Council [G0701945] Funding Source: researchfish
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Dynamic contrast-enhanced computed tomography (DCE-CT) assesses the vascular support of tumours through analysis of temporal changes in attenuation in blood vessels and tissues during a rapid series of images acquired with intravenous administration of iodinated contrast material. Commercial software for DCE-CT analysis allows pixel-by-pixel calculation of a range of validated physiological parameters and depiction as parametric maps. Clinical studies support the use of DCE-CT parameters as surrogates for physiological and molecular processes underlying tumour angiogenesis. DCE-CT has been used to provide biomarkers of drug action in early phase trials for the treatment of a range of cancers. DCE-CT can be appended to current imaging assessments of tumour response with the benefits of wide availability and low cost. This paper sets out guidelines for the use of DCE-CT in assessing tumour vascular support that were developed using a Delphi process. Recommendations encompass CT system requirements and quality assurance, radiation dosimetry, patient preparation, administration of contrast material, CT acquisition parameters, terminology and units, data processing and reporting. DCE-CT has reached technical maturity for use in therapeutic trials in oncology. The development of these consensus guidelines may promote broader application of DCE-CT for the evaluation of tumour vascularity. Key Points aEuro cent DCE-CT can robustly assess tumour vascular support aEuro cent DCE-CT has reached technical maturity for use in therapeutic trials in oncology aEuro cent This paper presents consensus guidelines for using DCE-CT in assessing tumour vascularity.
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