Journal
EUROPEAN RADIOLOGY
Volume 22, Issue 6, Pages 1320-1330Publisher
SPRINGER
DOI: 10.1007/s00330-012-2382-9
Keywords
DCE-MRI; Kidney; GFR; Quantification; Modeling
Funding
- Kidney Research UK
- Kidney Research UK [IN6/2010] Funding Source: researchfish
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Objective To model the uptake phase of T-1-weighted DCE-MRI data in normal kidneys and to demonstrate that the fitted physiological parameters correlate with published normal values. Methods The model incorporates delay and broadening of the arterial vascular peak as it appears in the capillary bed, two distinct compartments for renal intravascular and extravascular Gd tracer, and uses a small-vessel haematocrit value of 24%. Four physiological parameters can be estimated: regional filtration (ml min(-1) [ml tissue](-1)), perfusion (ml min(-1) [100 ml tissue](-1)), blood volume (%) and mean residence time MRT (s). From these are found the filtration fraction (; %) and total GFR (ml min(-1)). Fifteen healthy volunteers were imaged twice using oblique coronal slices every 2.5 s to determine the reproducibility. Results Using parenchymal ROIs, group mean values for renal biomarkers all agreed with published values: : 0.25; : 219; : 34; MRT: 5.5; : 15; GFR: 115. Nominally cortical ROIs consistently underestimated total filtration (by similar to 50%). Reproducibility was 7-18%. Sensitivity analysis showed that these fitted parameters are most vulnerable to errors in the fixed parameters kidney T-1, flip angle, haematocrit and relaxivity. Conclusions These renal biomarkers can potentially measure renal physiology in diagnosis and treatment. Key Points Dynamic contrast-enhanced magnetic resonance imaging can measure renal function. Filtration and perfusion values in healthy volunteers agree with published normal values. Precision measured in healthy volunteers is between 7 and 15%.
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