Journal
EUROPEAN RADIOLOGY
Volume 22, Issue 1, Pages 26-38Publisher
SPRINGER
DOI: 10.1007/s00330-011-2238-8
Keywords
Breast cancer; Magnetic resonance imaging; Sensitivity and specificity; Systematic review; Meta-analysis
Funding
- CIBER-ESP [AE08_006]
- Spanish Ministry of Health [FIS PI08/90193]
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To estimate the diagnostic accuracy of magnetic resonance imaging (MRI) in detecting additional lesions and contralateral cancer not identified using conventional imaging in primary breast cancer. We have conducted a systematic review and meta-analyses to estimate diagnostic accuracy indices and the impact of MRI on surgical management. Fifty articles were included (n = 10,811 women). MRI detected additional disease in 20% of women and in the contralateral breast in 5.5%. The summary PPV of ipsilateral additional disease was 67% (95% CI 59-74%). For contralateral breast, the PPV was 37% (95% CI 27-47%). For ipsilateral lesions, MRI devices a parts per thousand yen1.5 Tesla (T) had higher PPV (75%, 95% CI 64-83%) than MRI with < 1.5 T (59%, 95% CI 53-71%). Similar results were found for contralateral cancer, PPV 40% (95% CI 29-53%) and 19% (95% CI 8-39%) for high- and low-field equipments, respectively. True positive MRI findings prompted conversion from wide local excision (WLE) to more extensive surgery in 12.8% of women while in 6.3% this conversion was inappropriate. MRI shows high diagnostic accuracy, but MRI findings should be pathologically verified because of the high FP rate. Future research on this emerging technology should focus on patient outcome as the primary end-point. aEuro cent Breast Magnetic Resonance Imaging is becoming increasingly popular for cancer staging before surgery. aEuro cent This diagnostic accuracy systematic review and meta-analysis updates previous ones demonstrating MRI has high diagnostic accuracy and causes more extensive surgery. aEuro cent Magnetic Resonance protocols at 1.5 T or greater shows greater positive predictive value than lower-field equipments. aEuro cent The actual impact on clinical relevant outcomes should be addressed with properly designed randomized controlled trials.
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