Journal
EUROPEAN RADIOLOGY
Volume 20, Issue 2, Pages 432-442Publisher
SPRINGER
DOI: 10.1007/s00330-009-1556-6
Keywords
Magnetic resonance imaging; DCE-MRI; Pharmacokinetic modelling; MMID4; AIF
Funding
- Bundesministerium fur Bildung und Forschung (BMBF) [13N8873]
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The purpose was to compare two approaches for the acquisition and analysis of dynamic-contrast-enhanced MRI data with respect to differences in the modelling of the arterial input-function (AIF), the dependency of the model parameters on physiological parameters and their numerical stability. Eight hundred tissue concentration curves were simulated for different combinations of perfusion, permeability, interstitial volume and plasma volume based on two measured AIFs and analysed according to the two commonly used approaches. The transfer constants (Approach 1) K (trans) and (Approach 2) k (ep) were correlated with all tissue parameters. K (trans) showed a stronger dependency on perfusion, and k (ep) on permeability. The volume parameters (Approach 1) v (e) and (Approach 2) A were mainly influenced by the interstitial and plasma volume. Both approaches allow only rough characterisation of tissue microcirculation and microvasculature. Approach 2 seems to be somewhat more robust than 1, mainly due to the different methods of CA administration.
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