Journal
EUROPEAN PSYCHIATRY
Volume 25, Issue 5, Pages 268-271Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.eurpsy.2010.01.009
Keywords
Suicide; Suicidal behavior; Major depression; Epigenetics; Genetics; Environment; Whole-genome; Stress
Categories
Funding
- NIMH NIH HHS [R01 MH082041, MH82041, R10 MH056390-05, P50 MH062185-10, R01 MH082041-03, R01 MH048514-15, R01 MH056390, R10 MH056390, MH56390, MH62185, MH48514, P50 MH062185, R01 MH048514] Funding Source: Medline
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Alterations in a number of neurobiological systems have been associated with suicidal behavior including the serotonergic and noradrenergic systems and the hypothalamic-pituitary-adrenal axis. Altered functioning of these systems may stem from both genetic and developmental causes. Adversity in early-life has developmental consequences on these systems that persist into adulthood. Genetic differences may also contribute to alterations in functioning of neurobiological systems. Moreover, the interaction of early-life experiences of adversity and genetic vulnerability is increasingly thought to play a role, including via epigenetic mechanisms. (C) 2010 Elsevier Masson SAS. All rights reserved.
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