Journal
EUROPEAN POLYMER JOURNAL
Volume 57, Issue -, Pages 1-10Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2014.04.020
Keywords
pH responsive; Redox responsive; Spiropyran; Cell imaging; Micelle; Drug delivery
Categories
Funding
- industrial infrastructure program for fundamental technologies - Ministry of Trade, Industry & Energy (MOTIE, South Korea) [N00140008]
- MOTIE [R0001435, 10046506]
- Fusion Research R&D Program from the Korea Research Council for Industrial Science Technology [G02054]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10046506, R0001435] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This paper reports the development of multi-functionalized stimuli responsive polymeric micelle as a carrier to transport a hydrophobic drug, Taxol, with photo-responsive fluorescence polymer as an imaging agent. The formed micelle is responsive to acidic and higher redox environments due to the pH-responsive boronate ester and DTT-responsive disulfide bonds for triggered drug release, respectively. The polymeric micelle [PC-SPMA] was constructed using facile cross-linked polymerization [Plu-Ch] between phenylboronic acid-conjugated Pluronic (Plu-SS-BA) and lactose-modified chitosan (chitlac, Ch), and the spiropyran/boronic acid-conjugated poly(dimethylamino ethyl methacrylate-co-methacrylic acid) (S-PMA) was conjugated into Plu-Ch, which was confirmed by H-1 NMR, UV-vis and fluorescence spectroscopy and the size of the polymeric micelles were measured by dynamic light scattering (DLS). Drug-loaded micelles showed an ability to release the drug in response to mildly acidic and higher-DTT conditions. The prepared micelles show strong fluorescence due to the merocyanine (MC) form of spiropyran, which displayed the successful entrance of the micelles by confocal laser scanning microscopy (CLSM). This facile strategy can be a useful platform to stimulate the detection and delivery of anticancer drugs in cancer cells through imaging, and as a carrier of hydrophobic drugs based on intracellular environment. (C) 2014 Elsevier Ltd. All rights reserved.
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