4.7 Article

Preparation and drug release property of CO2 stimulus-sensitive poly(N, N-dimethylaminoethyl methacrylate)-b-polystyrene nanoparticles

Journal

EUROPEAN POLYMER JOURNAL
Volume 49, Issue 10, Pages 3165-3170

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2013.07.024

Keywords

Miniemulsion RAFT polymerization; CO2 stimulus-sensitive; Nanoparticles; Drug release

Funding

  1. Scientific Research Foundation for the Returned Overseas Chinese Scholars, the State Education Ministry [1001603-C]
  2. 521 Talents Training Plan in ZSTU
  3. Training Foundation for the Excellent Young Talents by the Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT), Ministry of Education [2011QN04]
  4. Innovative Program for Graduate Students of Zhejiang Sci-Tech University [YCX12011]

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The CO2 stimulus-sensitive nanoparticles based on poly(N, N-dimethylaminoethyl methacrylate)-b-poly styrene (PDMAEMA-b-PS) were prepared via surfactant-free miniemulsion reversible addition-fragmentation chain transfer (RAFT) polymerization. The as-prepared nanoparticles exhibited core-shell structure with about 120 nm in diameter. Their dispersion/aggregation in water can be adjusted by alternatively bubbling of CO2 and N-2. Drug release from these nanoparticles can be accelerated (or delayed) by bubbling (or removing) of CO2. (C) 2013 Elsevier Ltd. All rights reserved.

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