Journal
EUROPEAN POLYMER JOURNAL
Volume 44, Issue 11, Pages 3676-3687Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2008.08.021
Keywords
Block copolymers; Hybrid materials; Organic-inorganic hybrid polymer; Polymer synthesis
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Polypeptide/inorganic hybrid copolymers were obtained by a four-step synthetic approach combining (i) atom transfer polymerization of tert-butyl acrylate, (ii) chemical modification of the bromo end groups of ATRP-polymers into primary amino group using Gabriel reaction, (iii) ring opening polymerization of N-epsilon-trifluoroacetyl-L-lysine or gamma-benzyl-L-glutamate N-carboxyanhydrides followed by (iv) the transamidification reaction using a large excess of (3-aminopropyl)trimethoxysilane to substitute the tert-butyl groups of the poly(tert-butyl acrylate) block. Products were characterized using H-1 NMR, FT-IR, DSC and MALDI-TOF MS. These techniques proved that polymerization of tert-butyl acrylate was controlled whatever the molecular weight targeted and that bromide was quantitatively converted to amino end group by a original method leading to the synthesis of copolymers in the presence of N-carboxyanhydrides as monomers. Amphiphilic polypeptide/inorganic hybrid copolymers were then achieved. (C) 2008 Elsevier Ltd. All rights reserved.
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