Journal
ACS NANO
Volume 9, Issue 12, Pages 11628-11641Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b04866
Keywords
nanoparticle shape; nanoparticle stiffness; tumor imaging; macrophage uptake; iron oxide nanocubes
Categories
Funding
- European Research Council under the European Union's Seventh Framework Programme (FP7)/ERC [616695]
- Houston Methodist Research Institute
Ask authors/readers for more resources
Most nanoparticles for biomedical applications originate from the self-assembling of individual constituents through molecular interactions and possess limited geometry control and stability. Here, 1000 x 400 nm discoidal polymeric nanoconstructs (DPNs) are demonstrated by mixing hydrophobic and hydrophilic polymers with lipid chains and curing the resulting paste directly within silicon templates. By changing the paste composition, soft- and rigid-DPNs (s- and r-DPNs) are synthesized exhibiting the same geometry, a moderately negative surface electrostatic charge (-14 mV), and different mechanical stiffness (similar to 1.3 and 15 kPa, respectively). Upon injection in mice bearing nonorthotopic brain or skin cancers, s-DPNs exhibit similar to 24 h circulation half-life and accumulate up to similar to 20% of the injected dose per gram tumor, detecting malignant masses as small as similar to 0.1% the animal weight via PET imaging. This unprecedented behavior is ascribed to the unique combination of geometry, surface properties, and mechanical stiffness which minimizes s-DPN sequestration by the mononuclear phagocyte system. Our results could boost the interest in using less conventional delivery systems for cancer theranosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available