Journal
EUROPEAN NEUROPSYCHOPHARMACOLOGY
Volume 24, Issue 7, Pages 1086-1090Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.euroneuro.2014.01.015
Keywords
5-HTTLPR; Subjective sleep quality; Positive affect; Negative affect; Experience sampling method; Daily life
Funding
- Netherlands Organisation for Scientific Research
- Fund for Scientific research, Flanders and Twins
- Netherlands Organisation for Scientific Research (NWO, VENI) [916.76.147]
- ZON-MW [171001002]
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A link between sleep and affect is well-known. Serotonin (5-HT) is associated with the regulation of affective as well as sleep-related processes. A functional polymorphism in the serotonin transporter gene (5-HTTLPR) has been associated with serotonergic functioning. The present study investigated whether allelic variation of this gene moderates the association between nighttime subjective sleep quality and affect the following day. A population-based sample of 361 ethnically homogenous adult female twins underwent a five day protocol based on the experience sampling method (ESM), assessing momentary negative affect, positive affect, and subjective sleep quality repeatedly and prospectively. There was a significant interaction between sleep quality and genotype in predicting positive affect the next day: carriers of one (n=167) or two S-alleles (n=78) had a significantly steeper slope compared to LL carriers (n=116) (chi(2)=4.16, p=.042 and chi(2)=3.90, p=.048 respectively). The association between subjective sleep quality and positive affect the next day varied as a function of 5-HTTLPR: it was stronger in carriers of at least one copy of the S-allele compared to homozygous L-carriers, supporting a link between sleep and affect regulation, in which serotonin may play a role. However, these results are preliminary and require replication. (C) 2014 Elsevier B.V. and ECNP. All rights reserved.
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