Journal
EUROPEAN NEUROPSYCHOPHARMACOLOGY
Volume 24, Issue 12, Pages 1982-1999Publisher
ELSEVIER
DOI: 10.1016/j.euroneuro.2014.03.002
Keywords
Obesity; Adipokinesi; Brain; Leptin; Alzheimer; Dementia
Funding
- EU [211696]
- NIH/NIAID [1R01MH076537, 1R01MH079880, U01 318345]
- Swedish Research Council Diarienummer [523-2005-8460]
- State University of New York Research Foundation
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Obesity is a pandemic and a serious global health concern. Obesity is a risk factor for multiple conditions and contributes to multi-morbidities, resulting in increased health costs and millions of deaths each year. Obesity has been associated with changes in brain structure, cognitive deficits, dementia and Alzheimer's disease. Adipokines, defined as hormones, cytokines and peptides secreted by adipose tissue, may have more widespread influence and functionality in the brain than previously thought. In this review, six adipokines, and their actions in the obese and non-obese conditions will be discussed. Included are: plasminogen activator inhibitor-1 (PAI-1), interleukin-6 (IL-6), tumor necrosis factors alpha (TNF-alpha), angiotensinogen (AGT), adiponectin and leptin. Their functionality in the periphery, their ability to cross the blood brain barrier (BBB) and their influence on dementia processes within the brain will be discussed. (C) 2014 Elsevier By, and ECNP. All rights reserved.
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