Journal
EUROPEAN NEUROPSYCHOPHARMACOLOGY
Volume 21, Issue -, Pages S683-S693Publisher
ELSEVIER
DOI: 10.1016/j.euroneuro.2011.07.008
Keywords
Biological rhythms; Depression; Animal models
Funding
- NIDA NIH HHS [R01 DA023988, R01 DA023988-04] Funding Source: Medline
- NIMH NIH HHS [R01 MH082876, R01 MH082876-04] Funding Source: Medline
- NINDS NIH HHS [R21 NS058339-02, R21 NS058339] Funding Source: Medline
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Affective disorders such as major depression, bipolar disorder, and seasonal affective disorder are associated with major disruptions in circadian rhythms. Indeed, altered sleep/wake cycles are a critical feature for diagnosis in the DSM IV and several of the therapies used to treat these disorders have profound effects on rhythm length and stabilization in human populations. Furthermore, multiple human genetic studies have identified polymorphisms in specific circadian genes associated with these disorders. Thus, there appears to be a strong association between the circadian system and mood regulation, although the mechanisms that underlie this association are unclear. Recently, a number of studies in animal models have begun to shed light on the complex interactions between circadian genes and mood-related neurotransmitter systems, the effects of light manipulation on brain circuitry, the impact of chronic stress on rhythms, and the ways in which antidepressant and mood-stabilizing drugs alter the clock. This review will focus on the recent advances that have been gleaned from the use of pre-clinical models to further our understanding of how the circadian system regulates mood. (C) 2011 Elsevier B.V. and ECNP. All rights reserved.
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