Journal
EUROPEAN NEUROPSYCHOPHARMACOLOGY
Volume 21, Issue 12, Pages 885-891Publisher
ELSEVIER
DOI: 10.1016/j.euroneuro.2011.03.009
Keywords
Age; Dopamine; D-2 receptor; Striatal subdivisions; Positron emission tomography; Raclopride
Funding
- Korea Science and Engineering Foundation (KOSEF) [2010-0022796]
- Converging Research Center through the Ministry of Education, Science and Technology (MEST) [2010K001096]
- National Research Foundation of Korea [2010-0022796] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The purpose of the present study was to examine the relationship between age and dopamine D-2 receptor availability in striatal subdivisions of young and middle-aged healthy subjects using high-resolution positron emission tomography (PET) with [C-11]raclopride to better characterize the nature of age-related decrements in striatal D-2 receptor availability. Twenty-four healthy volunteers completed 3-Tesla magnetic resonance imaging and high-resolution [C-11]raclopride PET scans. The analyses using linear and exponential models revealed that age had a significant negative correlation with D-2 receptor availability in the post-commissural putamen (postPU) and that D-2 receptor binding in the postPU decreased significantly more with age than in the ventral striatum, suggesting subregional differences in age-related changes in D-2 receptor binding. The postPU, which belongs to the sensorimotor striatum, may be particularly vulnerable to the effects of age in young and middle-aged subjects. (C) 2011 Elsevier B.V. and ECNP. All rights reserved.
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