Journal
EUROPEAN NEUROPSYCHOPHARMACOLOGY
Volume 21, Issue 6, Pages 471-483Publisher
ELSEVIER
DOI: 10.1016/j.euroneuro.2010.09.006
Keywords
Social isolation; Prepulse inhibition; Social interaction; Clozapine; Schizophrenia; Animal model; Oxidative stress
Funding
- South African Medical Research Council
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Social isolation rearing (SIR) in rats induces behavioral and glutamatergic changes akin to schizophrenia. We studied the effects of 8 weeks SIR on cortico-striatal redox and social and cognitive behaviors in rats. SIR increased superoxide dismutase activity, decreased oxidized: reduced glutathione ratio and increased lipid peroxidation in both brain regions, and induced deficits in prepulse inhibition and social and self-directed interactive behaviors. Both behavioral and cortico-striatal redox disturbances were corrected by clozapine (5 mg/kg/day x 11 days). Behavioral changes evoked by SIR are associated with cortico-striatal oxidative stress that is reversed by clozapine treatment, providing novel insight into the neurobiology and treatment of schizophrenia. (C) 2010 Elsevier B.V. and ECNP. All rights reserved.
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