Journal
EUROPEAN NEUROPSYCHOPHARMACOLOGY
Volume 20, Issue 6, Pages 405-413Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.euroneuro.2010.02.013
Keywords
trans-Resveratrol; Forced swimming; Tail suspension; Serotonin; Noradrenaline; MAO
Funding
- Ellison Medical Foundation
- National Natural Science Foundation of China [30973892]
- Zhejiang Province Extremely Key Subject Building Funding Pharmacology and Biochemical Pharmaceutics
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The antidepressant-like effect of trans-resveratrol, a phenolic compound present in polygonum cuspidatum, was evaluated through behavioral and neurochemical methods. trans-Resveratrol (20, 40 and 80 mg/kg, via gavage) significantly decreased the immobility time in mouse models of despair tests, but did not influence locomotor activity. Two behavioral models and neurochemical assays suggested that trans-resveratrol produced a significant increase in serotonin and noradrenaline levels at 40 or 80 mg/kg in brain regions. In addition, trans-resveratrol dose dependently inhibited MAO-A activity. These findings indicate that the antidepressant-like effect of trans-resveratrol might be related to serotonergic and noradrenergic activation. Published by Elsevier B.V.
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