Journal
EUROPEAN NEUROPSYCHOPHARMACOLOGY
Volume 20, Issue 5, Pages 281-287Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.euroneuro.2010.02.005
Keywords
DISC1; Reelin; Very low-density lipoprotein receptor; Microtubules; Schizophrenia
Funding
- Office of the Dean of the Eastern Virginia Medical School
- Department of Psychiatry of Eastern Virginia Medical School
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Pathways associated with genes that regulate neuronal migration by influencing the function of microtubules in the developing fetal brain may be interfered with as part of the first-hit of schizophrenia. In the fully-developed brain, these same pathways that impact microtubule function mediate at least some aspects of experience-dependent plasticity, which may also be impaired in schizophrenia. Whereas severe presentations of lissencephaly are associated with mutations and deletions of DISC1, LIS1 and the gene for the very low-density lipoprotein receptor, genetic variations of these loci are good candidate schizophrenia genes. Importantly, in the fully-developed brain, there is a possibility that at least some of the consequences of these disturbed genetic pathways that adversely affect microtubule function may be bypassed or mitigated. (C) 2010 Elsevier B.V. and ECNP. All rights reserved.
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