Journal
EUROPEAN NEUROPSYCHOPHARMACOLOGY
Volume 19, Issue 1, Pages 53-63Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.euroneuro.2008.08.003
Keywords
Dopamine; Serotonin; Testosterone; Nucleus accumbens; Neostriatum; Intranasal; Microdialysis
Funding
- University of Dusseldorf
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Testosterone was administered intranasally in anesthetized mate rats, and its effects on the activity of dopaminergic and serotonergic neurons in the neostriatum and nucleus accumbens were assessed by means of microdialysis and HPLC. The treatment (0.5, 1.0 or 2.0 mg/kg of testosterone or vehicle, 10 mu l volume) was applied in both nostrils, half (5 mu l) into each. Subcutaneous injections of testosterone (2.0, 4.0 or 8.0 mg/kg) or vehicle were tested in other subjects. Samples were collected for 5 h. In the neostriatum, an increase of dopamine occurred after 2.0 mg/kg. Serotonin levels increased after 1.0 mg/kg dose. In the nucleus accumbens, dopamine and serotonin increased after 1.0 mg/kg and 2.0 mg/kg doses. Subcutaneous administration of 8.0 mg/kg testosterone increased dopamine and serotonin in the neostriatum only. We conclude that intranasal administration of testosterone is a more efficacious way for targeting the brain than the subcutaneous route, and may be considered as a means to activate central dopaminergic and serotonergic systems. (C) 2008 Elsevier B.V. and ECNP. All rights reserved.
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