Journal
EUROPEAN NEUROPSYCHOPHARMACOLOGY
Volume 19, Issue 5, Pages 349-355Publisher
ELSEVIER
DOI: 10.1016/j.euroneuro.2009.01.002
Keywords
BDNF; ECT; Plasma; Treatment-resistant depression; HRSD; Remission
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There is an increasing evidence that the Brain-Derived Neurotrophic Factor (BDNF) could be involved in the mode of action of antidepressants and, perhaps, of ECT This study aimed to investigate whether the clinical course of medication-resistant depressed patients following a course of ECT might be associated with changes of plasma BDNF concentrations. Our findings showed that at T0 (baseline) plasma BDNF levels of patients were significantly lower than those of control subjects, and that at T2 (after ECT) were significantly increased in parallel with the decrease of the Hamilton Rating Scale for Depression (HRSD) total score. However, only remitter patients who showed higher baseline BDNF levels than non-remitters reached normalized BDNF levels after ECT. These findings would suggest the potential usefulness of baseline plasma BDNF levels as predictors of response to ECT in treatment-resistant depressed patients. (C) 2009 Elsevier B.V. and ECNP. All rights reserved.
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