Journal
EUROPEAN NEUROPSYCHOPHARMACOLOGY
Volume 19, Issue 6, Pages 391-397Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.euroneuro.2008.12.010
Keywords
MDMA; Cocaine; Drug-seeking; Relapse; d-amphetamine; Reinstatement
Funding
- FIS [P1070709]
- Redes de grupos ISCIII [RTA G03/005]
- Ministerio de Ciencia y Tecnologia [SAF2007-64062]
- Genomics, mechanisms and treatment of addiction (GENADDICT) EC-DG RTD-FPVI-Life Sciences and Heatth-2003-IP [LSHM-CT-2004-05166]
- New motecules in mood disorders (NEWMOOD) EC-DG RTD-FPVI-Life Sciences and Health-2003-IP [LSHM-CT-2004-503474]
- PHECOMP [LSH-FP6037669]
- Generatitat de Catalunya [2005SGR00131]
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Background: MDMA effects are mediated by monoaminergic systems, which seem to play a central role in cocaine craving and relapse. Methods: CD1 mice trained to self-administer cocaine (1 mg/kg/infusion) underwent an extinction procedure in which the cues contingent with drug self-administration remained present. Mice achieving extinction were injected with MDMA (10 mg/kg), d-amphetamine (1 and 2 mg/kg) or saline and tested for reinstatement. Results: Acute MDMA, but not d-amphetamine or saline reinstated cocaine-seeking behaviour in mice in which cocaine self-administration and contingent cues were previously extinguished. Conclusions: Acute MDMA can reinstate cocaine-seeking behaviour in mice. (C) 2009 Elsevier B.V. and ECNP. All rights reserved.
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