Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 36, Pages 11598-11601Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b07463
Keywords
-
Categories
Funding
- US Department of Energy (DOE) (Division of Materials Sciences, Office of Basic Energy Sciences) [DE-FG02-10ER46677]
- DOE, Offices of Basic Energy Sciences and Biological and Environmental Research
- NIH
Ask authors/readers for more resources
We describe here the construction of a three-dimensional, porous, crystalline framework formed by spherical protein nodes that assemble into a prescribed lattice arrangement through metal-organic linker-directed interactions. The octahedral iron storage enzyme, ferritin, was engineered in its C-3 symmetric pores with tripodal Zn coordination sites. Dynamic light scattering and crystallographic studies established that this Zn-ferritin construct could robustly self-assemble into the desired bcc-type crystals upon coordination of a ditopic linker bearing hydroxamic acid functional groups. This system represents the first example of a ternary protein-metal-organic crystalline framework whose formation is fully dependent on each of its three components.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available