Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 26, Pages 8328-8331Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b03220
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Funding
- Canada Research Chair (Tier 1) foundation
- Natural Sciences and Engineering Research Council of Canada
- Fonds de recherchesur la nature et les technologies
- Canada Foundation for Innovation (CFI)
- McGill University
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The facile iodination of aromatic compounds under mild conditions is a great challenge for both organic and medicinal chemistry. Particularly, the synthesis of functionalized aryl iodides by light has long been considered impossible due to their photo-lability, which actually makes aryl iodides popular starting materials in many photo-substitution reactions. Herein, a photoinduced halogen exchange in aryl or vinyl halides has been discovered for the first time. A broad scope of aryl iodides can be prepared in high yields at room temperature under exceptionally mild conditions without any metal or photo-redox catalysts. The presence of a catalytic amount of elemental iodine could promote the reaction significantly.
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