4.8 Article

Catalytic Divergent Synthesis of 3H or 1H Pyrroles by [3+2] Cyclization of Allenoates with Activated Isocyanides

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 2, Pages 628-631

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja511895q

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Funding

  1. Singapore National Research Foundation (NRF Fellowship)
  2. National University of Singapore

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The cyclization of allenoates with activated isocyanides was reported for the first time. While Ag catalysis led to an unprecedented enantioselective synthesis of 3H pyrroles, a simple procedure using PPh3 produced a wide range of polysubstituted 1H pyrroles with high efficiency.

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