4.8 Article

Enzyme-Artificial Enzyme Interactions as a Means for Discriminating among Structurally Similar Isozymes

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 15, Pages 4892-4895

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b02496

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Funding

  1. Minerva Foundation
  2. International HFSP Organization
  3. European Research Council
  4. Council for Higher Education of Israeli Government

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We describe the design and function of an artificial enzyme-linked receptor (ELR) that can bind different members of the glutathione-S-transferase (GST) enzyme family. The artificial enzyme-enzyme interactions distinctly affect the catalytic activity of the natural enzymes, the biomimetic, or both, enabling the system to discriminate among structurally similar GST isozymes.

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