Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 33, Pages 10524-10527Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b07061
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Funding
- National Institutes of Health [GM46059, GM112218]
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The enantios elective, intramolecular hydro-alkylation of halide-tethered styrenes has been achieved through a copper hydride-catalyzed process. This approach allowed for the synthesis of enantioenriched cydobutanes, cyclopentanes, indanes, and six-membered N- and O-heterocycles. This protocol was applied to the synthesis of the commercial serotonin reuptake inhibitor (-)-paroxetine.
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