Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 21, Pages 6932-6940Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b03538
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Funding
- U.S. National Science Foundation [CHE-1506854]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1506854] Funding Source: National Science Foundation
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Chemoselective reactions for amide bond formation have transformed the ability to access synthetic proteins and other bioconjugates through ligation of fragments. In these ligations, amide bond formation is accelerated by transient enforcement of an intramolecular reaction between the carboxyl and the amine termini of two fragments. Building on this principle, we introduce an aldehyde capture ligation that parlays the high chemoselective reactivity of aldehydes and amines to enforce amide bond formation between amino acid residues and peptides that are difficult to ligate by existing technologies.
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