Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 11, Pages 3731-3734Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b01365
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Funding
- National Institute of General Medical Sciences [R01 GM107204]
- UNC Chapel Hill SURF fellowship
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A catalytic C-H alkylation using unactivated alkyl halides and a variety of arenes and heteroarenes is described. This ring-forming process is successful with a variety of unactivated primary and secondary alkyl halides, including those with beta-hydrogens. In contrast to standard polar or radical cyclizations of aromatic systems, electronic activation of the substrate is not required. the mild, catalytic reaction conditions are highly functional group tolerant and facilitate access to a diverse range of synthetically and medicinally important carbocyclic and heterocyclic systems.
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