Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 47, Pages 14952-14958Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b08533
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Funding
- National Institutes of Health [GM079359, GM111386, CA133086]
- National Key Scientific Program of China [2011CB911000]
- NSFC [NSFC 21221003, NSFC 21327009]
- China National Instrumentation Program [2011 YQ03012412]
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Inorganic colloidal nanopartides (NPs) stabilized by a layer of hydrophobic surfactant on their surfaces have poor solubility in the aqueous phase, thus limiting their application as biosensors under physiological conditions. Here we report a simple model to ionize various types of hydrophobic colloidal NPs, including Fe Pt, cubic Fe3O4, Pd, CdSe, and NaYF4 (Yb 30%, Er 2%, Nd 1%) NPs, to multicharged (positive and negative) NPs via ligand exchange. Surfaces of neutral hydrophobic NPs were converted to multicharged ions, thus making them soluble in water. Furthermore, peroxidase-like activity was observed for ionic Fe Pt, Fe3O4, Pd, and CdSe NPs, of which Fe Pt and CdSe catalyzed the oxidation of the colorless substrate 3,3',5,5'tetramethylbenzidine (TMB) to the blue-colored product in the absence of H2O2, while Pd and Fe3O4 catalyzed the oxidization of TMB in the presence of H2O2. With the benefit of the ionic functionalization protocols described herein, colloidal NPs should gain wider use as biomarkers, nanozymes, and biosensors.
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