Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 25, Pages 8113-8120Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b01177
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Funding
- Laserlab Europe access grant [LCVU001825]
- Chemical Sciences Council of The Netherlands Organization for Scientific Research its abbreviation (CW-NWO) through an ECHO
- Chemical Sciences Council of The Netherlands Organization for Scientific Research its abbreviation (CW-NWO) through a VICI grant
- BioSolar Cells program
- Harvest Marie Curie Research Training Network [PITN-GA-2009-238017]
- CW-NWO VIDI grant
- Leverhulme Trust
- U.K. Biotechnology and Biological Sciences Research Council
- BBSRC [BB/K00932X/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/K00932X/1] Funding Source: researchfish
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UVR8 is a novel UV-B photoreceptor that regulates a range of plant responses and is already used as a versatile optogenetic tool. Instead of an exogenous chromophore, UVR8 uniquely employs tryptophan side chains to accomplish UV-B photoreception. UV-B absorption by homodimeric UVR8 induces monomerization and hence signaling, but the underlying photodynamic mechanisms are not known. Here, by using a combination of time-resolved fluorescence and absorption spectroscopy from femto- to microseconds, we provide the first experimental evidence for the UVR8 molecular signaling mechanism. The results indicate that tryptophan residues at the dimer interface engage in photoinduced proton coupled electron transfer reactions that induce monomerization.
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