Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 5, Pages 1730-1733Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja5101307
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Funding
- NSF
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1437301] Funding Source: National Science Foundation
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Here we report the assembly of multilayered DNA nanocages. The layers can be separated in response to a chemical cue, ATP. This is an effort to increase the structural complexity of DNA nanocages. The structures have been characterized by native polyacrylamide gel electrophoresis, atomic force microscopy, and cryogenic electron microscopy. We envision that the layer-by-layer assembly strategy used in this study can be easily applied to other DNA nanocages to form Russian-doll-like semisolid structures, while the chemically activated layer separation makes a contribution to the development of smart DNA nanocages.
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