Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 28, Pages 8888-8891Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b04879
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Funding
- European Research Council [246837]
- Israel Science Foundation
- PBC, Israel
- DST-INSPIRE [DST/INSPIRE/04/2014/001130]
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The catalytic hydrogenation of nitriles to primary amines represents an atom-efficient and environmentally benign reduction methodology in organic chemistry. This has been accomplished in recent years mainly with precious-metal-based catalysts, With a single exception. Here We report the first homogeneous Co-catalyzed hydrogenation of nitriles to primary amines. Several (hetero)aromatic, benzylic, and aliphatic nitriles undergo hydrogenation to the corresponding primary amines in good to excellent yields under the reaction conditions.
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