Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 4, Pages 1404-1407Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja512242d
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Funding
- NSF [CHE-1058727, CHE-1363008, CHE-1416268]
- NIH [1R21EB018014, 2R15EB007074]
- DOD CDMRP [W81XWH-12-1-0159/BC112431]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1058727, 1416268, 1416432, 1363008] Funding Source: National Science Foundation
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Parahydrogen is demonstrated to efficiently transfer its nuclear spin hyperpolarization to nitrogen-15 in pyridine and nicotinamide (vitamin B-3 amide) by conducting signal amplification by reversible exchange (SABRE) at microtesla fields within a magnetic shield. Following transfer of the sample from the magnetic shield chamber to a conventional NMR spectrometer, the N-15 NMR signals for these molecules are enhanced by similar to 30,000- and similar to 20,000-fold at 9.4 T, corresponding to similar to 10% and similar to 7% nuclear spin polarization, respectively. This method, dubbed SABRE in shield enables alignment transfer to heteronuclei or SABRE-SHEATH, promises to be a simple, cost-effective way to hyperpolarize heteronuclei. It may be particularly useful for in vivo applications because of longer hyperpolarization lifetimes, lack of background signal, and facile chemical-shift discrimination of different species.
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