Journal
EUROPEAN JOURNAL OF RADIOLOGY
Volume 82, Issue 5, Pages E225-E231Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2012.12.014
Keywords
Magnetic resonance imaging; Hypertrophic cardiomyopathy; Fibrosis; Late gadolinium enhancement; T1 mapping
Funding
- Research Grant of National Natural Science Foundation of China [81000604]
- Youth Innovation Fund of Peking Medical College
- Chinese Academy of Medical Sciences [2012D04]
- Grant for Talent Research Star of Fuwai Hospital [2012-FWXX01]
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Purpose: To investigate the diagnostic value of T1 mapping imaging of evaluating fibrosis in patients with hypertrophic cardiomyopathy (HCM). Materials and methods: 21 subjects with HCM and 18 healthy volunteers underwent conventional late gadolinium enhancement (LGE) imaging and T1 mapping imaging. The region of myocardium in HCM is divided into remote area of LGE, peri-LGE, LGE (halo-like LGE and typical patchy LGE). These regions combined with normal volunteers' myocardium were calculated by the reduced percent of T1 value (RPTV). Results: The RPTV in healthy volunteers was no significant comparing with that in the remote area of LGE in HCM subjects (3.98 +/- 3.19 vs. 3.34 +/- 2.75, P > 0.05). There were significant statistical differences in pairwise among the remote area of LGE, peri-LGE, halo-like LGE and typical patchy LGE in the RPTV (P < 0.0001). ROC curves indicated that the T1 mapping imaging has a greater area under the curve comparing with that of traditional LGE imaging (0.975 perpendicular to 0.07 vs. 0.753 perpendicular to 0.26, P < 0.0001). Conclusions: HCM has a high prevalence of fibrosis and with varying severity. T1 mapping imaging can be a useful method to evaluate the severity of the fibrosis in HCM. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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