Journal
EUROPEAN JOURNAL OF RADIOLOGY
Volume 82, Issue 11, Pages E680-E685Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2013.08.004
Keywords
Sonoelastography; Shear wave; BI-RADS; Breast ultrasound; Breast masses
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2011-0007602]
- National Research Foundation of Korea [2011-0007602] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Purpose: To evaluate the interobserver agreement and the diagnostic performance of various qualitative features in shear-wave elastography (SWE) for breast masses. Materials and methods: A total of 153 breast lesions in 152 women who underwent B-mode ultrasound and SWE before biopsy were included. Qualitative analysis in SWE was performed using two different classifications: E values (Ecol; 6-point color score, Ehomo; homogeneity score and Esha; shape score) and a four-color pattern classification. Two radiologists reviewed five data sets: B-mode ultrasound, SWE, and combination of both for E values and four-color pattern. The BI-RADS categories were assessed B-mode and combined sets. Interobserver agreement was assessed using weighted kappa statistics. Areas under the receiver operating characteristic curve (AUC), sensitivity, and specificity were analyzed. Results: Interobserver agreement was substantial for Ecol (kappa = 0.79), Ehomo (kappa = 0.77) and four-color pattern (kappa = 0.64), and moderate for Esha (kappa = 0.56). Better-performing qualitative features were Ecol and four-color pattern (AUCs, 0.932 and 0.925) compared with Ehomo and Esha (AUCs, 0.857 and 0.864; P < 0.05). The diagnostic performance of B-mode ultrasound (AUC, 0.950) was not significantly different from combined sets with E value and with four color pattern (AUCs, 0.962 and 0.954). When all qualitative values were negative, leading to downgrade the BI-RADS category, the specificity increased significantly from 16.5% to 56.1% (E value) and 57.0% (four-color pattern) (P < 0.001) without improvement in sensitivity. Conclusion: The qualitative SWE features were highly reproducible and showed good diagnostic performance in suspicious breast masses. Adding qualitative SWE to B-mode ultrasound increased specificity in decision making for biopsy recommendation. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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