Journal
EUROPEAN JOURNAL OF RADIOLOGY
Volume 82, Issue 2, Pages 296-301Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2012.11.012
Keywords
Cardiovascular magnetic resonance imaging; Myocardial feature tracking; Strain; Quantification
Funding
- Philips Healthcare
- Bayer Schering Pharma
- British Heart Foundation (BHF) [RE/08/003, FS/10/029/28253]
- Biomedical Research Centre [BRC-CTF 196]
- American College of Cardiology Foundation
- Edna Ittner Pediatric Foundation
- Children's Hospital and Medical Center Foundation
- Wellcome Trust
- Engineering and Physical Sciences Research Council (EPSRC) [WT 088641/Z/09/Z]
- National Institute for Health Research (NIHR) via the comprehensive BRC award
- British Heart Foundation [FS/11/43/28760, FS/10/029/28253] Funding Source: researchfish
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Background: Cardiovascular magnetic resonance myocardial feature tracking (CMR-FT) is a promising novel method for quantification of myocardial wall mechanics from standard steady-state free precession (SSFP) images. We sought to determine whether magnetic field strength affects the intra-observer reproducibility of CMR-FT strain analysis. Methods: We studied 2 groups, each consisting of 10 healthy subjects, at 1.5 T or 3 T Analysis was performed at baseline and after 4 weeks using dedicated CMR-FT prototype software (Tomtec, Germany) to analyze standard SSFP cine images. Right ventricular (RV) and left ventricular (LV) longitudinal strain (Ell(RV) and Ell(LV)) and LV long-axis radial strain (Err(LAX)) were derived from the 4-chamber cine, and LV shor-taxis circumferential and radial strains (Ecc(SAX), Err(SAX)) from the short-axis orientation. Strain parameters were assessed together with LV ejection fraction (EF) and volumes. Intra-observer reproducibility was determined by comparing the first and the second analysis in both groups. Results: In all volunteers resting strain parameters were successfully derived from the SSFP images. There was no difference in strain parameters, volumes and EF between field strengths (p > 0.05). In general EccSAX was the most reproducible strain parameter as determined by the coefficient of variation (CV) at 1.5 T (CV 13.3% and 46% global and segmental respectively) and 3 T (CV 17.2% and 31.1% global and segmental respectively). The least reproducible parameter was EllRV (CV 1.5 T 28.7% and 53.2%; 3 T 43.5% and 63.3% global and segmental respectively). Conclusions: CMR-FT results are similar with reasonable intra-observer reproducibility in different groups of volunteers at 1.5 T and 3 T. CMR-FT is a promising novel technique and our data indicate that results might be transferable between field strengths. However there is a considerable amount of segmental variability indicating that further refinements are needed before CMR-FT can be fully established in clinical routine for quantitative assessment of wall mechanics and strain. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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