Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 26, Pages 8388-8391Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b05100
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Funding
- UCI
- National Institutes of Health [R01GM109078]
- National Science Foundation [CHE-1361104, CHE-1112409]
- OHSU-MRF
- Services Core of the Environmental Health Sciences Center [P30 ES00210]
- NSF [OCI-1053575]
- Direct For Mathematical & Physical Scien [1361104] Funding Source: National Science Foundation
- Division Of Chemistry [1361104] Funding Source: National Science Foundation
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1112409] Funding Source: National Science Foundation
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A new class of bioorthogonal reagents, 1,2,4-triazines, is described. These scaffolds are Stable in biological media and capable of robust reactivity with trans-cyclooctene (TCO). The enhanced stability of the triazine scaffold enabled its direct use in recombinant protein production. The triazine-TCO reaction can also be used in tandem with other bioorthogonal cycloaddition reactions. These features fill current voids in the bioorthogonal toolkit.
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