Journal
EUROPEAN JOURNAL OF RADIOLOGY
Volume 81, Issue 8, Pages E893-E896Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2012.04.027
Keywords
Prostate cancer; Positron emission tomography (PET); C-11-choline; PSA; Bone scan
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Aim: to evaluate the utility of C-11-choline PET/CT in prostate cancer (PC) patients who have demonstrated a biochemical recurrence and a negative bone scintigraphy (BS). Materials and methods: 123 consecutive PC patients (mean age 67.6 years; range 54-83) with a biochemical relapse (mean PSA value 3.3 ng/mL; range 0.2-25.5) after radical prostatectomy (RP) were included in our retrospective study. Patients underwent a BS that resulted negative and a C-11-choline PET/CT within 4 months from BS (range: 1 day to 4 months; mean: 2.5 months). Validation of results was established by: (1) a positive biopsy, (2) a positive subsequent BS, CT or MR and (3) a normalization of C-11-choline uptake after systemic therapy or a progression of the disease. Results: C-11-choline PET/CT was positive in 42/123 patients (34.1%). C-11-choline PET/CT detected lesions in: bone (10 patients), lymph-nodes (20 patients), bone and lymph nodes (7 patients), bone and lung (1 patient), lymph-nodes and lung (1 patient), local relapse (3 patients). Overall, C-11-choline PET/CT showed a total of 30 unknown bone lesions in 18/123 (14.6%) patients. Conclusion: C-11-choline PET/CT showed a better sensitivity than BS in patients with biochemical relapse after RP: C-11-choline PET/CT detected unknown bone lesions in 18/123 (14.6%) patients. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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