Journal
EUROPEAN JOURNAL OF RADIOLOGY
Volume 81, Issue 9, Pages 2154-2160Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2011.06.050
Keywords
Magnetic resonance imaging; Peripheral nerves injury; Mesenchymal stem cells; Stem cell transplantation
Funding
- National Natural Science Foundation of China [30400115]
- Natural Science Foundation of Guangdong Province [04300241]
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Objective: To assess the continuous process of nerve regeneration in acute peripheral nerve traction injury treated with mesenchymal stem cells (MSCs) transplantation using MRI. Materials and methods: 1 week after acute nerve traction injury was established in the sciatic nerve of 48 New Zealand white rabbits, 5 x 10(5) MSCs and vehicle alone were grafted to the acutely distracted sciatic nerves each in 24 animals. Serial MRI and T1 and T2 measurements of the injured nerves were performed with a 1.5-T scanner and functional recovery was recorded over a 10-week follow-up period, with histological assessments performed at regular intervals. Results: Compared with vehicle control, nerves grafted with MSCs had better functional recovery and showed improved nerve regeneration, with a sustained increase of T1 and T2 values during the phase of regeneration. Conclusion: MRI could be used to monitor the enhanced nerve regeneration in acute peripheral nerve traction injury treated with MSC transplantation, reflected by a prolonged increase in T1 and T2 values of the injured nerves. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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