Journal
EUROPEAN JOURNAL OF RADIOLOGY
Volume 70, Issue 2, Pages 227-231Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2009.01.045
Keywords
Photoacoustic imaging; Spectroscopic; Nanorods; Sentinel lymph node biopsy
Funding
- National Institutes of Health [R01 EB000712, R01 NS46214]
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Sentinel lymph node (SLN) biopsy has increasingly become important in axillary staging of breast cancer patients since SLN biopsy alleviates the postoperative complications of previously practiced axillary lymph node dissections. Nevertheless, the procedures of SLN biopsy using blue dye and radioactive substance are still intraoperative, and the latter methods are also ionizing. In this pilot study, we have proposed noninvasive in vivo spectroscopic photoacoustic (PA) SLN mapping using gold nanorods as lymph node tracers in a rat model. Gold nanorods have biocompatibility, high optical absorption, and easily tuned surface plasmon resonance peak wavelength. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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