Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 23, Pages 7302-7305Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b04425
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Funding
- National Institute of General Medical Sciences [NIH GM 084333]
- HHMI Fellowship (Kalamazoo College)
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Carbon, dioxide exhibits many of the qualities of an ideal reagent: it is nontoxic, plentiful, and inexpensive. Unlike other gaseous reagents, however, it has found limited use in enantioselective synthesis. Moreover, unprecedented is a tool that merges one of the Simplest biological :approaches to catalysis-Bronsted acid/base activation with this abundant reagent. We describe a metal-free small molecule catalyst that achieves the three component reaction between a homoallylic alcohol, carbon dioxide, and an electrophilic Source of iodine. Cyclic carbonates are formed enantioselectively.
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