Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 1, Pages 90-93Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja511422q
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Funding
- National Natural Science Foundation of China
- National Basic Research Program of China [2012CB821600]
- 111 project of the Ministry of Education of China [B06005]
- National Program for Support of Top-notch Young Professionals
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A highly efficient asymmetric hydrogenation of cyclic imines containing a pyridyl moiety was established by using iridium catalysts with chiral spiro phosphine-oxazoline ligands. This process will facilitate the development of new nicotine-related pharmaceuticals. The introduction of a substituent at the ortho position of the pyridyl ring to reduce its coordinating ability ensures the success of the hydrogenation and excellent enantioselectivity.
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