Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 8, Pages 3017-3023Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja5122809
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Funding
- CRI project [2009-0081566]
- National Research Foundation of the Ministry of Science, ICT AMP
- Future Planning in Korea [2012R1A1A2006259]
- Rural development Administration in Korea [PJ009041022012]
- National Research Foundation of Korea (NRF) - Korea government (MEST) [NSF-2013R1A1A1A05011990, 2012M3A9B4028636]
- National Research Foundation of Korea [2012R1A1A2006259] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Rural Development Administration (RDA), Republic of Korea [PJ009041022012] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Mitochondria are organelles that are readily susceptible to temperature elevation. We selectively delivered a coumarin-based fluorescent iron oxide nanoparticle, Mito-CIO, to the mitochondria. Upon 740 nm laser irradiation, the intracellular temperature of HeLa cells was elevated by 2.1 degrees C within 5 min when using Mito-CIO, and the treatment resulted in better hyperthermia and a more elevated cytotoxicity than HeLa cells treated with coumarin iron oxide (CIO), which was missing the mitochondrial targeting unit. We further confirmed these results in a tumor xenograft mouse model. To our knowledge, this is the first report of a near-infrared laser irradiation-induced hyperthermic particle targeted to mitochondria, enhancing the cytotoxicity in cancer cells. Our present work therefore may open a new direction in the development of photothermal therapeutics.
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