Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 674, Issue 2-3, Pages 359-364Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2011.10.040
Keywords
Atherosclerosis; Tanshinone IIA; Oxidized low density lipoprotein; Superoxide dismutase; Glutathione peroxidase
Categories
Funding
- People's Government of Guangdong Province, PR of China [2003A30904]
- Ministry of Education, PR of China [104146]
- Key Natural Science Fund of Guangdong Province, PR of China [04105349]
- Key Program of Guangdong Province, PR of China [2003B31713]
- Key Program of Guangzhou City, PR of China [2003Z1-E5011]
- Scientific and Technology Agency of Guangzhou City [2006Z3-E4021]
- China Postdoctoral Foundation [20060400225]
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Oxidative stress plays a crucial role in atherogenesis, which raises the possibility of using antioxidants to ameliorate atherosclerosis. In the present study, we aim to determine the effects of tanshinone IIA (TSIIA) on atherosclerosis in hyperlipidemic rabbits. After feeding the rabbits on a high-lipid diet for 90 days, they developed severe atherosclerotic lesions both morphologically and biochemically and exhibited significantly elevated serum lipid, malondialdehyde (MDA) and oxidized low density lipoprotein (oxLDL) levels. Oral administration of TSIIA (3-30 mg/kg) greatly inhibited the formation of atherosclerotic lesions. In TSIIA-treated rabbits, there was a marked reduction in serum and aortic lipid peroxide product content, represented by MDA and oxLDL, whereas enhanced activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were observed. However. TSIIA had no effect on serum lipid profiles. These results suggest that TSIIA attenuates oxidative stress by decreasing oxLDL production and enhancing activities of SOD and GPx, which might be contributed to the amelioration of atherosclerosis. (C) 2011 Elsevier B.V. All rights reserved.
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